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17 条记录 (耗时 0.026 秒)

    Pyranobenzoxadiazole derivatives
    2.
    发明授权
    Pyranobenzoxadiazole derivatives 失效
    苯并恶唑衍生物

    公开(公告)号：US4900752A

    公开(公告)日：1990-02-13

    申请号：US304641

    申请日：1989-02-01

    申请人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Kyoko Nakayama ,  Ryozo Sakoda ,  Yukinori Masuda

    发明人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Kyoko Nakayama ,  Ryozo Sakoda ,  Yukinori Masuda

    IPC分类号： C07D491/052 ,  A61K31/352 ,  A61K31/41 ,  A61K31/4245 ,  A61P9/02 ,  A61P9/12 ,  A61P11/06 ,  C07D20060101 ,  C07D498/04

    CPC分类号： C07D498/04

    摘要： A compounds of the formula (I): ##STR1## wherein A represents OH or OC(O)CH.sub.3-n X.sub.n, B represents hydrogen atom, or A and B together represent a bond; R.sup.1 represents hydrogen atom, R.sup.2 represents hydrogen atom, C(Z)CH.sub.3-n X.sub.n or C(Z)NHCH.sub.3-n X.sub.n or R.sup.1 and R.sup.2 together represents (CH.sub.2).sub.m, (CH.sub.2).sub.m-1 C(Z), N(R.sup.3)(CH.sub.2).sub.2 C(Z), (CH.sub.2).sub.m-2 NHC(Z) or (CH.sub.2).sub.m-2 OC(Z) in which X represents fluorine atom, chlorine atom, bromine atom, a methyl group or a methoxy group and n represents 0 or an integer of 1 to 3, Z represents oxygem atom or sulfur atom, m represents an integer of 4 or 5 and R.sup.3 represents hydrogen atom or a methyl group, and pharmacological acceptable salts of the compounds which can form salts, processes therefor and pharmaceutical use of the compounds.

    摘要翻译： 本发明包括式（I）的化合物：其中A表示OH或OC（O）CH 3 -n Xn，B表示氢原子，或A和B一起表示键; R 1表示氢原子，R 2表示氢原子，C（Z）CH 3 -n Xn或C（Z）NHCH 3 -n X n或R 1和R 2一起表示（CH 2）m， ）m-1C（Z），N（R 3）（CH 2）2 C（Z），（CH 2）m -NHHC（Z）或（CH 2）m -OOC（Z） 原子，溴原子，甲基或甲氧基，n表示0或1〜3的整数，Z表示氧原子或硫原子，m表示4或5的整数，R 3表示氢原子或 甲基和可以形成盐的化合物的药理学可接受的盐，其制备方法，化合物的药物用途和包含该化合物的组合物。

    Tricyclic benzopyrane compound
    3.
    发明授权
    Tricyclic benzopyrane compound 有权
    三环苯并吡喃化合物

    公开(公告)号：US07964623B2

    公开(公告)日：2011-06-21

    申请号：US12591353

    申请日：2009-11-17

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/429 ,  C07D513/06

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R1和R2彼此独立地为氢原子，C1-6烷基或C6-14芳基，R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键，R 4为氢原子，或与R 3一起形成键，m为0〜4的整数，n为0〜4的整数，V为单键，CR 7 R 8， NR9，O，S，SO或SO2，R5是氢原子或C1-6烷基，R6是氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，氨基，C1-6烷基氨基， C 1-6烷基氨基，C 6-14芳基氨基，C 2-9杂芳基氨基，C 6-14芳基，C 2-9杂芳基或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环作为构成原子 的环，氧原子，氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3，包括待稠合的苯环的不饱和键，构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。

    Optically active bidentate phosphine ligand palladium complex
    4.
    发明授权
    Optically active bidentate phosphine ligand palladium complex 失效
    光活性二齿膦配体钯络合物

    公开(公告)号：US5880301A

    公开(公告)日：1999-03-09

    申请号：US894520

    申请日：1997-09-16

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Kazuhiko Ohrai

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Kazuhiko Ohrai

    IPC分类号： B01J31/24 ,  C07F15/00 ,  C07F9/02

    CPC分类号： B01J31/2295 ,  B01J31/2409 ,  B01J31/2414 ,  B01J31/2452 ,  C07F15/0066 ,  B01J2231/4272 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/842

    摘要： The present invention provides a novel optically active bidentate phosphine ligand palladium complex of formula (I) or (II) which can be used for the preparation of optically active .beta.-hydroxyketones: ##STR1## �wherein Y.sup.- represents an anion pair which may form salt; X represents ##STR2## {wherein R.sup.1 represents hydrogen atom, C.sub.1-6 alkyl group, C.sub.1-6 alkoxyl group, cyano group, nitro group, halogen atom or phenyl group, etc.; m represents 1 or 2; when m is 2, two R.sup.1 s may be same or different}; andA and B each independently represents phenyl group or cyclohexyl group {said phenyl group and cyclohexyl group each is unsubstituted or substituted by R.sup.2 (R.sup.2 has the same meaning as defined in R.sup.1)}).

    摘要翻译： PCT No.PCT / JP96 / 00418 Sec。 371日期：1997年9月16日 102（e）日期1997年9月16日PCT提交1996年2月23日PCT公布。 出版物WO96 / 26210 日期：1996年8月29日本发明提供了可用于制备光学活性β-羟基酮的式（I）或（II）的新型光学活性二齿膦配体钯络合物： （II）[其中Y-表示可形成盐的阴离子对; X代表原子，C 1-6烷基，C 1-6烷氧基，氰基，硝基，卤原子或苯基等; m表示1或2; 当m为2时，两个R1可以相同或不同}; A和B各自独立地表示苯基或环己基（所述苯基和环己基各自未被取代或被R 2取代（R 2具有与R 1中定义相同的含义）}）。

    Substituted benzopyran derivatives against arrhythmia
    6.
    发明授权
    Substituted benzopyran derivatives against arrhythmia 失效
    取代苯并吡喃衍生物抗心律失常

    公开(公告)号：US07041700B2

    公开(公告)日：2006-05-09

    申请号：US10479118

    申请日：2002-06-17

    申请人： Yoshio Ohara ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    发明人： Yoshio Ohara ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    IPC分类号： A61K31/35

    CPC分类号： C07D311/68

    摘要： This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent

    摘要翻译： 本发明涉及式（1）或式（2）的苯并吡喃衍生物，其中R 1和R 2各自独立地表示氢原子或C 1-6个烷基，R 3表示羟基或C 1-6烷基羰基氧基，R 4表示氢原子或 C 1-6烷基，R 5表示被C 6-14烷基取代的C 1-6烷基。 芳基或杂芳基，R 6表示C 1-6烷基，C 1-6烷氧基，卤素原子，硝基， C（O）NH 2，C（O）NHR 8或C（O）NR 8 R 9， ，或其药学上可接受的盐。 这些化合物可用作抗心律失常药

    Tricyclic benzopyrane compound
    8.
    发明申请
    Tricyclic benzopyrane compound 有权
    三环苯并吡喃化合物

    公开(公告)号：US20100069374A1

    公开(公告)日：2010-03-18

    申请号：US12591353

    申请日：2009-11-17

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/542 ,  A61K31/5383 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/436 ,  A61K31/429 ,  A61K31/424 ,  A61K31/4188 ,  A61K31/4162 ,  A61K31/407 ,  C07D513/04 ,  C07D498/04 ,  C07D491/052 ,  A61P9/06

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R1和R2彼此独立地为氢原子，C1-6烷基或C6-14芳基，R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键，R 4为氢原子，或与R 3一起形成键，m为0〜4的整数，n为0〜4的整数，V为单键，CR 7 R 8， NR9，O，S，SO或SO2，R5是氢原子或C1-6烷基，R6是氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，氨基，C1-6烷基氨基， C 1-6烷基氨基，C 6-14芳基氨基，C 2-9杂芳基氨基，C 6-14芳基，C 2-9杂芳基或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环作为构成原子 的环，氧原子，氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3，包括待稠合的苯环的不饱和键，构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。

    Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents
    9.
    发明申请
    Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents 有权
    三环苯并吡喃复合物作为抗心律不齐剂

    公开(公告)号：US20080004262A1

    公开(公告)日：2008-01-03

    申请号：US10590975

    申请日：2005-03-23

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/436 ,  A61K31/403 ,  A61K31/495 ,  A61K31/517 ,  A61K31/538 ,  A61P9/06 ,  C07D209/56 ,  C07D221/02 ,  C07D235/02 ,  C07D241/36 ,  C07D265/38 ,  C07D515/12

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R 1和R 2彼此独立地为氢原子，C C 1-6烷基或C 6-14芳基，R 3是氢原子或C 1-6 >烷基羰氧基，或与R 4连接形成键，R 4是氢原子，或与R 3 3一起形成键，m 为0〜4的整数，n为0〜4的整数，V为单键，CR 7，R 8，NR 9， >，O，S，SO或SO 2，R 5是氢原子或C 1-6烷基，R 6 C 1-6烷基，C 3-8环烷基，C 3-8环烯基，C 3-8环烷基，C 3-6环烷基， 氨基，C 1-6烷基氨基，二-C 1-6烷基氨基，C 6-14芳基氨基，C 2-9个杂芳基氨基，C 6-14-14芳基，C 2-9 - 杂芳基 A或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环，作为环的构成原子，氧原子，氮原子或硫原子可以 单独或以其组合存在1〜3的数量，环中的不饱和键数为1,2或3，包括要被稠合的苯环的不饱和键，构成环的碳原子可以是羰基 或硫代羰基。 这些化合物可用作抗心律不齐剂。

    4-oxybenzopyran derivative
    10.
    发明授权
    4-oxybenzopyran derivative 失效
    4-羟基苯并吡喃衍生物

    公开(公告)号：US06677371B1

    公开(公告)日：2004-01-13

    申请号：US10069002

    申请日：2002-03-29

    申请人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    发明人： Keizo Tanikawa ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    IPC分类号： A61K3135

    CPC分类号： C07D311/22

    摘要： This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group; R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, an aryl group or a heteroaryl group; R5 represents a hydrogen atom or a C1-6 alkyl group; X is absent or represents C═O or SO2; R6 represents a hydrogen atom, a C1-6 alkyl group or a C3-6 cycloalkyl group; R7 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

    摘要翻译： 本发明涉及式（I）的4-氧代苯并吡喃衍生物，其中R 1和R 2各自独立地表示氢原子，C 1-6烷基或苯基; R 3表示羟基或C 1-6烷基羰基氧基; R 4表示氢原子，C 3-6环烷基，C 1-6烷基，C 1-6烷基羰基，C 1-6烷基氨基羰基，二-C 1-6烷基氨基羰基，芳基或 杂芳基; R 5表示氢原子或C 1-6烷基; X不存在或表示C = O或SO 2; R 6表示氢原子，C 1-6烷基或C 3-6环烷基; R 7表示氢原子，卤素原子，硝基或氰基; 或其药学上可接受的盐。 本发明还涉及一种用于治疗对包含所述化合物或其药学上可接受的盐作为活性成分的具有对功能不应期的延长作用的心律的药物。