发明授权
US07964631B2 Fused tricyclic compounds as inhibitors of tumor necrosis factor-α
失效
融合三环化合物作为肿瘤坏死因子-α的抑制剂
- 专利标题： Fused tricyclic compounds as inhibitors of tumor necrosis factor-α
- 专利标题（中）： 融合三环化合物作为肿瘤坏死因子-α的抑制剂
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申请号： US12854745申请日： 2010-08-11
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公开(公告)号： US07964631B2公开(公告)日： 2011-06-21
- 发明人: Bansi Lal , Somesh Sharma , Usha Ghosh , Swati Bal-Tembe , Tulsidas More , Pravin Gagare , Sunil Jadhav , Shashikant Patil , Asha Kulkarni-Almeida , Sapna Parikh , Radha Bhaskar Panicker , Anagha Damre , Ravindra Gupte
- 申请人： Bansi Lal , Somesh Sharma , Usha Ghosh , Swati Bal-Tembe , Tulsidas More , Pravin Gagare , Sunil Jadhav , Shashikant Patil , Asha Kulkarni-Almeida , Sapna Parikh , Radha Bhaskar Panicker , Anagha Damre , Ravindra Gupte
- 申请人地址： IN Mumbai
- 专利权人： Piramal Life Sciences Limited
- 当前专利权人： Piramal Life Sciences Limited
- 当前专利权人地址： IN Mumbai
- 代理机构： Merchant & Gould P.C.
- 优先权： IN1226/MUM/2004 20041110
- 主分类号： A61K31/38
- IPC分类号： A61K31/38
摘要：
Compounds of formula 1: are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-α) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-α activity, in particular inflammations.
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