发明授权
US07968591B2 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments
有权
1,3-二取代的4-甲基-1H-吡咯-2-甲酰胺及其在药物中的用途
- 专利标题： 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments
- 专利标题（中）： 1,3-二取代的4-甲基-1H-吡咯-2-甲酰胺及其在药物中的用途
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申请号： US12331011申请日： 2008-12-09
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公开(公告)号： US07968591B2公开(公告)日： 2011-06-28
- 发明人: Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
- 申请人： Stefan Oberboersch , Bernd Sundermann , Corinna Sundermann , Edward Bijsterveld , Hagen-Heinrich Hennies
- 申请人地址： DE Aachen
- 专利权人： Gruenenthal GmbH
- 当前专利权人： Gruenenthal GmbH
- 当前专利权人地址： DE Aachen
- 代理机构： Crowell & Moring LLP
- 优先权： DE102006027229 20060609
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61K31/55 ; A61K31/541 ; A61K31/5377 ; A61K31/4439 ; A61K31/4545 ; A61K31/454 ; A61K31/433 ; A61K31/4178 ; A61K31/404 ; A61K31/4025 ; A61K31/40 ; C07D417/12 ; C07D413/04 ; C07D405/04 ; C07D407/04 ; C07D401/14 ; C07D401/12 ; C07D401/06 ; C07D403/12 ; C07D207/34
摘要：
1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.
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