发明授权
- 专利标题： Recombinant attenuated clostridium organisms and vaccine
- 专利标题（中）： 重组减毒梭菌生物体和疫苗
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申请号： US12869813申请日： 2010-08-27
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公开(公告)号： US07972604B2公开(公告)日： 2011-07-05
- 发明人: Mark D. Cochran , Gary R. Peterson , Stephen V. Lair , Richard M. Synenki
- 申请人： Mark D. Cochran , Gary R. Peterson , Stephen V. Lair , Richard M. Synenki
- 申请人地址： US NJ Summit
- 专利权人： Intervet Inc.
- 当前专利权人： Intervet Inc.
- 当前专利权人地址： US NJ Summit
- 主分类号： A61K39/02
- IPC分类号： A61K39/02
摘要：
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
公开/授权文献
- US20110008389A1 RECOMBINANT ATTENUATED CLOSTRIDIUM ORGANISMS AND VACCINE 公开/授权日：2011-01-13
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