公开(公告)号：US20240358815A1

公开(公告)日：2024-10-31

申请号：US18684161

申请日：2022-08-19

申请人： Intervet Inc.

发明人： Erwin Van Den Born ,  Carina Leifeld ,  Amaya Serrano Garcia ,  Holger Hönemann ,  Alexandra Jimenez Melsio ,  Kimberly Pietersz

IPC分类号： A61K39/135 ,  A61K39/00

CPC分类号： A61K39/135 ,  A61K2039/5258 ,  C12N2770/32123 ,  C12N2770/32134 ,  C12N2770/32152

摘要： The invention concerns a method of producing a foot and mouth disease virus (FMDV) virus-like particle (VLP) in a baculovirus expression system, the method comprising the steps of (i) infecting an insect cell with a baculovirus expression vector, (ii) culturing the insect cell in cell culture medium for 5 days or more post infection and (iii) harvesting the FMDV VLP from the cell culture medium. The invention further relates to a vaccine for use in the protection of a subject against an infection with FMDV, the vaccine being obtainable by the method of the invention.

公开(公告)号：US20240284890A1

公开(公告)日：2024-08-29

申请号：US18570341

申请日：2022-06-29

申请人： INTERVET INC.

发明人： Joep BOLWERK ,  Evert GIJTENBEEK ,  Gijsbert Johan VAN DUIJN ,  Peter JANS

IPC分类号： A01M1/02 ,  G06T7/00

CPC分类号： A01M1/026 ,  G06T7/00 ,  A01M2200/011 ,  G06T2207/30242

摘要： A method for counting bird parasites (22) by capturing an image of a target area (20) that the parasites are expected to cross, and using image recognition techniques for discerning the parasites, characterized in that the target area (20) is a portion of a substrate (12) on which birds (10) are kept and which has a topography with low time variation, and the method comprises a step of counting incidents of temporary local disturbance of the topography of the target area.

公开(公告)号：US12018020B2

公开(公告)日：2024-06-25

申请号：US17311560

申请日：2019-12-12

申请人： Intervet Inc.

发明人： Christophe Pierre Alain Chassaing ,  Xiaoling Jin ,  Rositza Iordanova Petrova ,  Richard J. Varsolona ,  Lorenzo Codan ,  Edward Cleator ,  Adrian Goodyear ,  Jonathan Simmons ,  Tanja Schweisel

IPC分类号： C07D405/14

CPC分类号： C07D405/14 ,  C07B2200/13

摘要： The present application relates to crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide and processes for the preparation thereof. The compound is useful for the treatment of JAK-mediated diseases or conditions such as atopic dermatitis.

公开(公告)号：US11980170B2

公开(公告)日：2024-05-14

申请号：US16769325

申请日：2018-12-19

申请人： Intervet Inc.

发明人： Russel Howe ,  Zachary Lizer ,  James Wallace Sarrett ,  Peter Jon Abrahamson ,  Jascha Tucker Little

IPC分类号： A01K61/13 ,  G05B15/02 ,  G06T1/00

CPC分类号： A01K61/13 ,  G05B15/02 ,  G06T1/00

摘要： A method for external fish parasite monitoring in aquaculture, comprising the steps of: —submerging a camera in a sea pen comprising fish; —capturing images of the fish with the camera; and —identifying external fish parasite on the fish by analyzing the captured images, characterized by the steps of: —distinguishing between at least two different classes of external fish parasite which differ in the difficulty of recognizing the external fish parasite; —calculating quality metrics for each captured image, the quality metrics permitting to identify the classes of external fish parasite for which the quality of the image is sufficient for lice detection.

公开(公告)号：US20240123057A1

公开(公告)日：2024-04-18

申请号：US18163038

申请日：2023-02-01

申请人： Intervet Inc.

发明人： Stephanie Cook ,  Mohamad Morsey ,  Ian Tarpey ,  Iwan Verstegen ,  Paulus Jacobus Antonius Sondermeijer ,  Paul Vermeij

IPC分类号： A61K39/245 ,  A61P31/22 ,  C12N7/00

CPC分类号： A61K39/245 ,  A61P31/22 ,  C12N7/00 ,  A61K2039/5256

摘要： The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.

公开(公告)号：US20240057565A1

公开(公告)日：2024-02-22

申请号：US18495894

申请日：2023-10-27

申请人： Intervet Inc.

发明人： Russel Howe ,  Zachary Lizer ,  James Wallace Sarrett ,  Peter Jon Abrahamson ,  Jascha Tucker Little

IPC分类号： A01K61/13 ,  G01S17/04 ,  A01K63/06 ,  G01S17/08 ,  G03B15/03 ,  G03B17/56 ,  H04N23/61 ,  H04N23/67

CPC分类号： A01K61/13 ,  G01S17/04 ,  A01K63/06 ,  G01S17/08 ,  G03B15/03 ,  G03B17/561 ,  H04N23/61 ,  H04N23/671 ,  G03B2215/0567 ,  G03B2215/0578

摘要： A system for external fish parasites monitoring in aquaculture, the system comprising:



a camera (52) suitable to be submerged in a sea pen suitable for containing comprising fish, the camera being arranged for capturing images of the fish; and
an electronic image processing system (86) configured for identifying external fish parasites on the fish by analyzing the captured images,
wherein:
a ranging detector (54) configured for detecting the presence of fish and measuring a distance from the detector to the fish is mounted adjacent to the camera (52); and
an electronic control system (12) is arranged to control a focus of the camera (52) on the basis of the measured distance and to trigger the camera (52) when a fish has been detected within a predetermined distance range.

公开(公告)号：US20240053340A1

公开(公告)日：2024-02-15

申请号：US18257896

申请日：2021-12-23

申请人： INTERVET INC.

发明人： Erwin Van Den Born ,  Urs Peter Bruderer

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/01 ,  G01N2469/20

摘要： The invention relates to a diagnostic use of an African Swine Fever Vims CD2v protein, a method, a device, and a kit for the detection of the presence of ASFV antibodies in a test sample, in particular the use thereof in a DIVA immunoassay.

公开(公告)号：US20240024446A1

公开(公告)日：2024-01-25

申请号：US18257600

申请日：2021-12-21

申请人： Intervet Inc.

发明人： Maarten Hendrik Witvliet ,  Ruud Philip Antoon Maria Segers ,  Mateusz Walczak

IPC分类号： A61K39/00 ,  A61P39/00

CPC分类号： A61K39/0013 ,  A61P39/00 ,  A61K2039/6081

摘要： The present invention pertains to the use of conjugated aflatoxin (AFB) in a method to protect an animal against AFB induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, immune suppression, icterus, hemorrhagic enteritis as a result of the ingestion of AFB.

公开(公告)号：US11878006B2

公开(公告)日：2024-01-23

申请号：US17390258

申请日：2021-07-30

申请人： Intervet Inc.

发明人： Annie Flochlay-Sigognault ,  Anne Lehay

IPC分类号： A61K31/42 ,  A61P33/00 ,  A61K31/355 ,  A61K31/422 ,  A61K47/22

CPC分类号： A61K31/42 ,  A61K31/355 ,  A61K31/422 ,  A61K47/22 ,  A61P33/00

摘要： For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.

公开(公告)号：US11741731B2

公开(公告)日：2023-08-29

申请号：US17867613

申请日：2022-07-18

申请人： Intervet Inc.

发明人： Pavel Vácha ,  Petr Jankuj ,  Richard Josef Marhoefer ,  Václav Belák ,  Jind{hacek over (r)}ich Soukup ,  Brunhilde Schölzke ,  Britta von Oepen

IPC分类号： G06V20/00 ,  G06V20/69 ,  G06T7/00

CPC分类号： G06V20/698 ,  G06V20/693 ,  G06V20/695 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30004

摘要： A parasite analysis system includes a pressure vessel configured to store a biological sample, an imaging cell connected to the pressure vessel, and a waste depository connected to the imaging cell. An input valve controls whether biological sample can flow from the pressure vessel into the imaging cell and an output valve controls whether biological sample can flow from the imaging cell into the waste depository. The parasite analysis system also includes a camera that captures a chronological set of images of a portion of the biological sample in the imaging cell and an image analysis system that analyzes the chronological set of images to generate an estimate of a number of parasites in the portion of the biological sample. Estimates for multiple portions of the biological sample may be generated and sampling techniques used to estimate the number of parasites in the entire biological sample.