发明授权
US07973041B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
有权
取代的环状异羟肟酸盐作为基质金属蛋白酶的抑制剂
- 专利标题: Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
- 专利标题(中): 取代的环状异羟肟酸盐作为基质金属蛋白酶的抑制剂
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申请号: US12070310申请日: 2008-02-15
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公开(公告)号: US07973041B2公开(公告)日: 2011-07-05
- 发明人: Yun-Long Li , Jincong Zhuo , David M. Burns , Wenqing Yao , Ravi Kumar Jalluri
- 申请人: Yun-Long Li , Jincong Zhuo , David M. Burns , Wenqing Yao , Ravi Kumar Jalluri
- 申请人地址: US DE Wilmington
- 专利权人: Incyte Corporation
- 当前专利权人: Incyte Corporation
- 当前专利权人地址: US DE Wilmington
- 代理机构: Fish & Richardson P.C.
- 主分类号: A61K31/497
- IPC分类号: A61K31/497
摘要:
The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites thereof, and pharmaceutically acceptable salts, wherein the ring A substituent groups are fully defined in the following disclosure. The compounds of formula are inhibitors of metalloproteases such as matrix metalloproteases and sheddases, and are useful in treating diseases such as rheumatoid arthritis, psoriasis, neoplastic diseases, allergies and all those diseases wherein inhibition of MMPs is desirable.
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