发明授权
- 专利标题： Derivatives of alkylpiperazine- and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors
- 专利标题（中）： 烷基哌嗪和烷基高哌嗪羧酸衍生物的制备方法及其与脂肪酸酰氨基水解酶抑制剂的应用
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申请号： US12334798申请日： 2008-12-15
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公开(公告)号： US07973042B2公开(公告)日： 2011-07-05
- 发明人: Ahmed Abouabdellah , Antonio Almario Garcia , Christian Hoornaert , Tak Adrien Li
- 申请人： Ahmed Abouabdellah , Antonio Almario Garcia , Christian Hoornaert , Tak Adrien Li
- 申请人地址： FR Paris
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： FR Paris
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 代理商 Serena Farquharson-Torres
- 优先权： FR0401953 20040226
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; C07D295/00 ; A61K31/4965
摘要：
The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.