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1.发明授权Derivatives of alkylpiperazine- and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors 失效烷基哌嗪和烷基高哌嗪羧酸衍生物的制备方法及其与脂肪酸酰氨基水解酶抑制剂的应用公开(公告)号：US07973042B2
公开(公告)日：2011-07-05
申请号：US12334798
申请日：2008-12-15
IPC分类号： C07D241/04 , C07D295/00 , A61K31/4965
CPC分类号： C07D295/185 , C07D209/16 , C07D215/20 , C07D215/26 , C07D231/12 , C07D239/26 , C07D243/08 , C07D295/205
摘要： The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
摘要翻译： 本发明包括烷基哌嗪和烷基高哌嗪羧酸盐及其衍生物，其制备方法及其作为脂肪酸酰氨基水解酶（FAAH）酶抑制剂的治疗用途。 这些衍生物通过与大麻素和香草素受体的相互作用发挥各种药理活性。 通过抑制FAAH酶的代谢活性，不会产生常常引起疾病发病和其他病理状况的化合物，并且疾病的发病率大大降低。
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2.发明授权Derivatives of alkylpiperazine and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors 失效烷基哌嗪和烷基高哌嗪羧酸盐的衍生物及其制备方法及其与脂肪酸酰氨基水解酶抑制剂的用途公开(公告)号：US07482346B2
公开(公告)日：2009-01-27
申请号：US11466192
申请日：2006-08-22
IPC分类号： A61K31/50 , A61K31/501 , A61K31/497 , A61K31/4965 , C07D403/00 , C07D401/00 , C07D241/04 , C07D295/00
CPC分类号： C07D295/185 , C07D209/16 , C07D215/20 , C07D215/26 , C07D231/12 , C07D239/26 , C07D243/08 , C07D295/205
摘要： The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
摘要翻译： 本发明包括烷基哌嗪和烷基高哌嗪羧酸盐及其衍生物，其制备方法及其作为脂肪酸酰氨基水解酶（FAAH）酶抑制剂的治疗用途。 这些衍生物通过与大麻素和香草素受体的相互作用发挥各种药理活性。 通过抑制FAAH酶的代谢活性，不会产生常常引起疾病发病和其他病理状况的化合物，并且疾病的发病率大大降低。
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3.发明申请DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS 失效烷基哌嗪和烷基二磷杂环己烷羧酸酯的衍生物，其制备方法及其作为脂肪酸氨基水解酶酶抑制剂的用途公开(公告)号：US20090143365A1
公开(公告)日：2009-06-04
申请号：US12334798
申请日：2008-12-15
IPC分类号： A61K31/551 , C07D241/04 , A61K31/495 , A61K31/496 , A61P9/00 , A61P37/00 , A61P1/00 , A61P31/00 , A61P35/00 , A61P25/00 , C07D413/02 , C07D243/08
CPC分类号： C07D295/185 , C07D209/16 , C07D215/20 , C07D215/26 , C07D231/12 , C07D239/26 , C07D243/08 , C07D295/205
摘要： The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
摘要翻译： 本发明包括烷基哌嗪和烷基高哌嗪羧酸盐及其衍生物，其制备方法及其作为脂肪酸酰氨基水解酶（FAAH）酶抑制剂的治疗用途。 这些衍生物通过与大麻素和香草素受体的相互作用发挥各种药理活性。 通过抑制FAAH酶的代谢活性，不会产生常常引起疾病发病和其他病理状况的化合物，并且疾病的发病率大大降低。
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