发明授权
US07973143B2 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
有权
鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
- 专利标题： Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
- 专利标题（中）： 鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
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申请号： US12341520申请日： 2008-12-22
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公开(公告)号： US07973143B2公开(公告)日： 2011-07-05
- 发明人: Julie D. Saba , Jianhui Zhou
- 申请人： Julie D. Saba , Jianhui Zhou
- 申请人地址： US CA Oakland
- 专利权人： Children's Hospital & Research Center at Oakland
- 当前专利权人： Children's Hospital & Research Center at Oakland
- 当前专利权人地址： US CA Oakland
- 代理机构： Seed IP Law Group PLLC
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; C07K16/00 ; G01N33/573
摘要：
Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
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