A lifting reel with a four-line wire structure includes a fixed body fixed to a ceiling of a structure, first and second drums installed to the body at a predetermined interval and rotated by a driving motor, wires respectively connected to the first and second drums, and first, second, third and fourth guide rollers arranged on a top of a lifting body at regular intervals and suspended on the wires to form a four-line wire. A wire-twisting prevention device is installed between an end of the wire connected to the first drum and an end of the wire connected to the second drum so as to connect both wires with each other. The wire-twisting prevention device includes bearings installed to the ends of the wires to be rotatable, respectively. The bearings prevent the wires from being twisted while the wires are wound around or unwound from the drums.