Invention Grant
- Patent Title: Nitro-imidazole hypoxia imaging agent
- Patent Title (中): 硝基咪唑缺氧显像剂
-
Application No.: US12836926Application Date: 2010-07-15
-
Publication No.: US07977361B2Publication Date: 2011-07-12
- Inventor: Thomas Lee Collier , Brian A. Duclos , Umesh B. Gangadharmath , Zhiyong Gao , Farhad Karimi , Dhanalakshmi Kasi , Hartmuth C. Kolb , Qianwa Liang , Henry Clifton Padgett , Joseph C. Walsh , Tieming Zhao
- Applicant: Thomas Lee Collier , Brian A. Duclos , Umesh B. Gangadharmath , Zhiyong Gao , Farhad Karimi , Dhanalakshmi Kasi , Hartmuth C. Kolb , Qianwa Liang , Henry Clifton Padgett , Joseph C. Walsh , Tieming Zhao
- Applicant Address: US PA Malvern
- Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee: Siemens Medical Solutions USA, Inc.
- Current Assignee Address: US PA Malvern
- Agent Joshua B. Ryan
- Main IPC: C07D249/04
- IPC: C07D249/04 ; A61K31/4192
Abstract:
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
Public/Granted literature
- US20110002850A1 Nitro-Imidazole Hypoxia Imaging Agent Public/Granted day:2011-01-06
Information query
