Disclosed are multiple embodiments of method and apparatus to facilitate Multiple Users Reusing One Timeslot (MUROS) operation in wireless communications. A pair of wireless transmit/receive units (WTRUs) may be multiplexed onto a timeslot using a same pulse format. A WTRU may communicate on a network using MUROS technology both on the downlink (DL) and the uplink (UL), and may use a first pulse format on the DL and a second different pulse format on the UL. Pulse format support information to facilitate MUROS operation may be communicated between a network and a WTRU. The support information may be communicated in Radio Resource Control (RRC) messages. A network may allow for concurrent operation of WTRUs using different types of MUROS technology. For example, a network may include WTRUs using MUROS based on orthogonal sub-channels (OSC) while other WTRUs use MUROS based on an interference-canceling technology such as Downlink Advanced Receiver Performance (DARP) Phase I or Phase II.