发明授权
- 专利标题： 4-amino 5-cyanopyrimidine derivatives
- 专利标题（中）： 4-氨基-5-氰基嘧啶衍生物
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申请号： US12923451申请日： 2010-09-22
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公开(公告)号： US07989446B2公开(公告)日： 2011-08-02
- 发明人: Masaya Kato , Norifumi Sato , Minoru Okada , Tetsuyuki Uno , Nobuaki Ito , Yasuhiro Takeji , Hisashi Shinohara , Masahiro Fuwa
- 申请人： Masaya Kato , Norifumi Sato , Minoru Okada , Tetsuyuki Uno , Nobuaki Ito , Yasuhiro Takeji , Hisashi Shinohara , Masahiro Fuwa
- 申请人地址： JP Tokyo
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： JP2004-135999 20040430
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; A61K31/506
摘要：
The present invention provides 4-amino-5-cyanopyrimidine derivatives of the formula: wherein R1, R2 and R3 are defined herein, or pharmaceutically acceptable salts thereof, having a safe and potent adenosine A2a receptor agonistic activity; and also provides an adenosine A2a receptor agonist, an intraocular pressure reducing agent, or a medicine for treating glaucoma, etc., which comprises the compound as an active ingredient.
公开/授权文献
- US20110009620A1 4-Amino-5-cyanopyrimidine derivatives 公开/授权日：2011-01-13