发明授权
- 专利标题： 4,5-dihydro-oxazol-2-yl amine derivatives
- 专利标题（中）： 4,5-二氢 - 恶唑-2-基胺衍生物
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申请号： US12369782申请日： 2009-02-12
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公开(公告)号： US07989449B2公开(公告)日： 2011-08-02
- 发明人: Matteo Andreini , Emanuele Gabellieri , Wolfgang Guba , Guido Marconi , Robert Narquizian , Eoin Power , Massimiliano Travagli , Thomas Woltering , Wolfgang Wostl
- 申请人： Matteo Andreini , Emanuele Gabellieri , Wolfgang Guba , Guido Marconi , Robert Narquizian , Eoin Power , Massimiliano Travagli , Thomas Woltering , Wolfgang Wostl
- 申请人地址： US NJ Nutley IT Siena
- 专利权人： Hoffman-La Roche Inc.,Siena Biotech S.p.A.
- 当前专利权人： Hoffman-La Roche Inc.,Siena Biotech S.p.A.
- 当前专利权人地址： US NJ Nutley IT Siena
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权： EP08151546 20080218
- 主分类号： A61K31/421
- IPC分类号： A61K31/421 ; A61K31/506 ; A61K31/4439 ; A61K31/538 ; C07D263/28 ; C07D413/10
摘要：
The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceutically active acid addition salts thereof. Compounds of the invention have Asp2 (β-secretase, BACE 1 or Memapsin-2) inhibitory activity and are useful for the treatment of diseases characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
公开/授权文献
- US20090209529A1 4,5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES 公开/授权日：2009-08-20
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