发明授权
US07989629B2 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders
失效
3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂用于治疗炎性和/或过敏性疾病
![3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders](/docs/US/2011-08-02/US07989629B2/abs.jpg.600x600.jpg)
- 专利标题： 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders
- 专利标题（中）： 3-（4 - {[4-（4 - {[3-（3,3-二甲基-1-哌啶基）丙基]氧基}苯基）-1-哌啶基]羰基} -1-萘基）丙酸或丙烯酸 H1和H3受体拮抗剂用于治疗炎性和/或过敏性疾病
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申请号： US12158185申请日： 2006-12-19
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公开(公告)号： US07989629B2公开(公告)日： 2011-08-02
- 发明人: Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Maria Victoria Vinader Brugarolas
- 申请人： Simon Teanby Hodgson , Panayiotis Alexandrou Procopiou , Maria Victoria Vinader Brugarolas
- 申请人地址： GB Greenford, Middlesex
- 专利权人： Glaxo Group Limited
- 当前专利权人： Glaxo Group Limited
- 当前专利权人地址： GB Greenford, Middlesex
- 代理商 James P. Riek
- 优先权： GB0525897.5 20051220; GB0623217.7 20061121
- 国际申请： PCT/EP2006/069943 WO 20061219
- 国际公布： WO2007/071691 WO 20070628
- 主分类号： C07D211/20
- IPC分类号： C07D211/20 ; A61K31/451
![3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders](/abs-image/US/2011/08/02/US07989629B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.