公开(公告)号：US20180127389A1

公开(公告)日：2018-05-10

申请号：US15624417

申请日：2017-06-15

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D295/033 ,  C07D211/20 ,  C07D243/08 ,  C07D211/70 ,  C07D295/096

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

公开(公告)号：US09006445B2

公开(公告)日：2015-04-14

申请号：US14342253

申请日：2012-09-06

Applicant: Clas Sonesson ,  Thomas Pittelkow ,  Brian Frøstrup ,  Anne Zimmermann

Inventor： Clas Sonesson ,  Thomas Pittelkow ,  Brian Frøstrup ,  Anne Zimmermann

IPC: C07D211/20 ,  C07D211/30 ,  C07D211/24

CPC classification number: C07D211/30 ,  C07D211/24

Abstract: This invention relates to a new crystalline form of Pridopidine, a drug substance currently in development for the treatment of Huntington's disease. More specifically the invention provides polymorphic Form II of the Pridopidine hydrochloride salt, a process for the preparation of this polymorphic form, pharmaceutical compositions comprising polymorphic Form II, and methods of uses of this polymorphic form.

Abstract translation: 本发明涉及一种新的结晶形式的派多定，目前正在开发用于治疗亨廷顿氏病的药物。 更具体地，本发明提供了盐酸普拉头德盐的多晶型II，该多晶形式的制备方法，包含多晶型II的药物组合物，以及该多晶型物的使用方法。

公开(公告)号：US20150073018A1

公开(公告)日：2015-03-12

申请号：US14542210

申请日：2014-11-14

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Tine Bryan Stensbol ,  Silke Miller ,  Heidi Lopez De Diego

IPC: C07D211/20

CPC classification number: C07D211/20 ,  C07B2200/13 ,  C07C55/08 ,  C07C55/12 ,  C07C59/08 ,  C07C229/24

Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided, e.g., for the treatment of neuropathic pain.

Abstract translation: 提供4- [2-（4-甲基苯基硫基） - 苯基]哌啶及其盐的结晶形式，例如用于治疗神经性疼痛。

公开(公告)号：US08735585B2

公开(公告)日：2014-05-27

申请号：US13584872

申请日：2012-08-14

Applicant: Bo Qu ,  Anjan Saha ,  Jolaine Savoie ,  Xudong Wei ,  Nathan K. Yee

Inventor： Bo Qu ,  Anjan Saha ,  Jolaine Savoie ,  Xudong Wei ,  Nathan K. Yee

IPC: C07D221/16 ,  C07D211/20 ,  C07D255/00 ,  A61K31/44

CPC classification number: C07D221/16 ,  C07D213/57 ,  C07D221/06

Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors.

Abstract translation: 公开了式（I）的化合物及其盐。 还公开了制备式（I）化合物的方法和该化合物作为中间体用于制备药学活性化合物如11-羟基类固醇类氢化酶1型（11-bgr-HSD1）抑制剂的方法。

公开(公告)号：US08653106B2

公开(公告)日：2014-02-18

申请号：US12846936

申请日：2010-07-30

Applicant: Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol

Inventor： Clifford Riley King ,  Stephen G. D'Ambrosio ,  David W. Bristol

IPC: A01N43/40 ,  A61K31/445 ,  A01N33/02 ,  A61K31/135 ,  C07D211/20 ,  C07C211/00

CPC classification number: A61K31/4458 ,  A61K31/137 ,  A61K31/485 ,  A61K31/55

Abstract: A pharmaceutical composition comprising a drug substance consisting essentially of a pharmaceutically acceptable organic acid addition salt of an amine containing pharmaceutically active compound wherein the amine containing pharmaceutical active compound is selected from the group consisting of racemic or single isomer ritalinic acid or phenethylamine derivatives and the drug substance has a physical form selected from amorphous and polymorphic.

公开(公告)号：US20130316248A9

公开(公告)日：2013-11-28

申请号：US12499446

申请日：2009-07-08

Applicant: Nikolai Ignatyev ,  Michael Schmidt ,  Udo Heider ,  Peter Sartori ,  Andry Kucheryna

Inventor： Nikolai Ignatyev ,  Michael Schmidt ,  Udo Heider ,  Peter Sartori ,  Andry Kucheryna

IPC: H01M6/16 ,  H01G9/022 ,  B01F1/00 ,  B01J31/02 ,  C07D211/20 ,  H01M6/04 ,  H01M10/40 ,  C07C309/13 ,  C07D233/64 ,  C07D207/30 ,  C07C309/06 ,  H01M6/18

CPC classification number: H01G9/038 ,  C07C303/26 ,  C07C309/65 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/023 ,  C07D295/037 ,  C07F9/5407 ,  C07F9/65688 ,  H01G9/022 ,  H01G11/56 ,  H01G11/62 ,  H01M10/0525 ,  H01M10/0568 ,  Y02E60/13

Abstract: The invention relates to a method for producing perfluoroalkanesulfonic acid esters and for further transforming the same into the salts thereof. The invention also relates to the use of the produced compounds in electrolytes, batteries, capacitors, supercapacitors, and galvanic cells.

公开(公告)号：US07989629B2

公开(公告)日：2011-08-02

申请号：US12158185

申请日：2006-12-19

Applicant: Simon Teanby Hodgson ,  Panayiotis Alexandrou Procopiou ,  Maria Victoria Vinader Brugarolas

Inventor： Simon Teanby Hodgson ,  Panayiotis Alexandrou Procopiou ,  Maria Victoria Vinader Brugarolas

IPC: C07D211/20 ,  A61K31/451

CPC classification number: C07D211/20

Abstract: The present invention relates to a compound of formula (I), or a salt thereof wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7 or 8 position by R1, and R1 represents —CH2CH2COOH or —CH═C(CH3)COOH, and to processes for their preparation, to compositions containing them and to their use in the treatment of various inflammatory and/or allergic diseases, such as diseases such as allergic rhinitis.

Abstract translation: 本发明涉及式（I）化合物或其盐，其中萘环在取代的2,3,4,5,6,7或8位，R1表示-CH2CH2COOH或-CH （C 3）COOH，以及其制备方法，含有它们的组合物及其在治疗各种炎症和/或过敏性疾病例如过敏性鼻炎等疾病中的用途。

公开(公告)号：US20110039890A1

公开(公告)日：2011-02-17

申请号：US12747628

申请日：2008-12-11

Applicant: Benny Bang-Andersen ,  Morten Jorgensen ,  Andre Faldt ,  Neil Anderson ,  Tine Bryan Stensbol

Inventor： Benny Bang-Andersen ,  Morten Jorgensen ,  Andre Faldt ,  Neil Anderson ,  Tine Bryan Stensbol

IPC: A61K31/451 ,  C07D211/20 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P25/16 ,  A61P25/22

CPC classification number: C07D211/20

Abstract: The compound 4-[2,3-Difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine according to the structure (formula I), and pharmaceutically acceptable salts thereof are provided for the treatment of CNS related disorders, such as: depressive disorder, dysthymic disorder; mood disorder due to a general medical condition; atypical depression; seasonal affective disorder; melancholia; treatment resistant depression; partial responders; depression associated with bipolar disorder, pain, Alzheimer's disease, psychosis, Parkinson's disease, Lewy body disease, Huntington's disease, multiple sclerosis or anxiety; general anxiety disorder, social anxiety disorder, panic attacks; phobia; social phobia, obsessive compulsive disorder; post traumatic stress disorder, acute stress; ADHD; and pain.

Abstract translation: 根据结构（式I）的化合物4- [2,3-二氟-6-（2-氟-4-甲基 - 苯硫基） - 苯基] - 哌啶及其药学上可接受的盐被用于治疗CNS 相关疾病，如：抑郁障碍，精神抑郁障碍; 一般情况下情绪障碍; 非典型抑郁症 季节性情绪失调; 忧郁症 耐药抑郁症; 部分回应者 与双相障碍，疼痛，阿尔茨海默病，精神病，帕金森病，路易体病，亨廷顿病，多发性硬化或焦虑有关的抑郁症; 一般焦虑症，社会焦虑症，惊恐发作; 恐怖症; 社交恐惧症，强迫症; 创伤后应激障碍，急性应激; 多动症 和痛苦。

公开(公告)号：US20100234604A1

公开(公告)日：2010-09-16

申请号：US12722711

申请日：2010-03-12

Applicant: Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

Inventor： Xin Linghu ,  Kathleen Linn ,  Kevin M. Maloney ,  Mark McLaughlin ,  Gang Qian

IPC: C07D211/20 ,  C07D213/62

CPC classification number: C07D213/79 ,  C07D211/24

Abstract: The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.

公开(公告)号：US20100105730A1

公开(公告)日：2010-04-29

申请号：US12527907

申请日：2008-03-14

Applicant: Gudrun Lasskogen ,  Tine Bryan Stensbol ,  Heidi Lopez de Diego

Inventor： Gudrun Lasskogen ,  Tine Bryan Stensbol ,  Heidi Lopez de Diego

IPC: A61K31/445 ,  C07D211/20 ,  A61P25/00

CPC classification number: A61K31/451 ,  A61K9/0095 ,  C07D211/20

Abstract: Liquid formulations of the DL-lactic acid, the glutaric acid, the L-aspartic acid and the glutamic acid salts of 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine and their use in the manufacture of a medicament to be used in the treatment of CNS diseases are provided.

Abstract translation: 4- [2-（4-甲基苯基硫烷基）苯基]哌啶的DL-乳酸，戊二酸，L-天冬氨酸和谷氨酸盐的液体制剂及其在制备用于 提供CNS疾病的治疗。