Invention Grant
- Patent Title: Exo- and diastereo-selective syntheses of himbacine analogs
- Patent Title (中): 烟草类似物的外切和非对映选择性合成
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Application No.: US12505079Application Date: 2009-07-17
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Publication No.: US07989653B2Publication Date: 2011-08-02
- Inventor: George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-Iong Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
- Applicant: George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-Iong Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
- Applicant Address: US NJ Kenilworth
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Current Assignee Address: US NJ Kenilworth
- Agent Mark W. Russell; Catherine D. Fitch
- Main IPC: C07C69/608
- IPC: C07C69/608
Abstract:
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
Public/Granted literature
- US20090281321A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS Public/Granted day:2009-11-12
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