发明授权
US07993651B2 Chimeric human immunodeficiency virus (HIV) immunogens comprising GAG P24-P17 fused to multiple cytotoxic T lymphocyte (CTL) epitopes
失效
包含与多种细胞毒性T淋巴细胞（CTL）表位融合的GAG P24-P17的嵌合人免疫缺陷病毒（HIV）免疫原
- 专利标题： Chimeric human immunodeficiency virus (HIV) immunogens comprising GAG P24-P17 fused to multiple cytotoxic T lymphocyte (CTL) epitopes
- 专利标题（中）： 包含与多种细胞毒性T淋巴细胞（CTL）表位融合的GAG P24-P17的嵌合人免疫缺陷病毒（HIV）免疫原
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申请号： US10168843申请日： 2000-12-22
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公开(公告)号： US07993651B2公开(公告)日： 2011-08-09
- 发明人: Tomas Hanke , Andrew McMichael
- 申请人： Tomas Hanke , Andrew McMichael
- 申请人地址： GB London US NY New York KE Nairobi
- 专利权人： Medical Research Council,International AIDS Vaccine Initiative,University of Nairobi
- 当前专利权人： Medical Research Council,International AIDS Vaccine Initiative,University of Nairobi
- 当前专利权人地址： GB London US NY New York KE Nairobi
- 代理机构： Vedder Price P.C.
- 代理商 Thomas J. Kowalski; Deborah L. Lu
- 优先权： GB9930294.5 19991223; GB0025234.6 20001014
- 国际申请： PCT/GB00/04984 WO 20001222
- 国际公布： WO01/47955 WO 20010705
- 主分类号： A61K39/21
- IPC分类号： A61K39/21
摘要：
Disclosed is an immunogen in sterile form suitable for administration to a human subject, the immunogen comprising: at least a portion of the gag protein of HIV, said gag protein being from an HIV clade or having a consensus sequence for one or more HIV clades, and comprising at least parts of p17 and p24; and a synthetic polypeptide comprising a plurality of amino acid sequences, each sequence comprising a human CTL epitope of an HIV protein, and wherein a plurality of HIV proteins are represented in the synthetic polypeptide, said CTL epitopes being selected to stimulate an immune response to one or more HIV clades of interest.
公开/授权文献
- US20030108562A1 Immune responses to hiv 公开/授权日：2003-06-12
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