Invention Grant
US07998719B2 Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof
有权
再生肝脏1（PRL-1）多肽的磷酸酶的晶体及其结晶方法
- Patent Title: Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof
- Patent Title (中): 再生肝脏1（PRL-1）多肽的磷酸酶的晶体及其结晶方法
-
Application No.: US11587404Application Date: 2005-04-26
-
Publication No.: US07998719B2Publication Date: 2011-08-16
- Inventor: Seong Eon Ryu , Dae Gwin Jeong , Seung-Jun Kim , Jae Hoon Kim , Jeong Hee Son
- Applicant: Seong Eon Ryu , Dae Gwin Jeong , Seung-Jun Kim , Jae Hoon Kim , Jeong Hee Son
- Applicant Address: KR Taejeon-Si
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Taejeon-Si
- Agency: Licata & Tyrrell P.C.
- Priority: KR10-2004-0028774 20040426
- International Application: PCT/KR2005/001202 WO 20050426
- International Announcement: WO2005/103242 WO 20051103
- Main IPC: C12N9/16
- IPC: C12N9/16
Abstract:
The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and monomers form a trimer through farnesylation site in the C-terminus of said protein. Thus intra-cellular migration and membrane localization can be achieved. The said crystal structure of PRL-1 protein of the present invention is very useful for the development the agent which inhibits carcinogenesis and metastasis of the cancer.
Public/Granted literature
- US20090117580A1 Structure of prl-1 protein crystal and the method of crystallization thereof Public/Granted day:2009-05-07
Information query
