发明授权
US07998975B2 Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
有权
含氮稠环衍生物,含有衍生物的药物组合物及其作为药物的用途
- 专利标题: Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
- 专利标题(中): 含氮稠环衍生物,含有衍生物的药物组合物及其作为药物的用途
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申请号: US12032411申请日: 2008-02-15
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公开(公告)号: US07998975B2公开(公告)日: 2011-08-16
- 发明人: Nobuhiko Fushimi , Hirotaka Teranishi , Kazuo Shimizu , Shigeru Yonekubo , Fumiaki Ito , Masayuki Isaji
- 申请人: Nobuhiko Fushimi , Hirotaka Teranishi , Kazuo Shimizu , Shigeru Yonekubo , Fumiaki Ito , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2004-61426 20040304
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; A61K31/405 ; A01N43/38
摘要:
The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula R1 represent H, an optionally substituted alkyl group, an alkenyl group, etc.; R2 represent H, a halogen atom or an alkyl group; R3 and R4 represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; Y represents CH or N; Q represents alkylene, alkenylene, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G-1) or (G-2) (in which E1 represents H, F or OH; and E2 represents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.
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