发明授权
US07998984B2 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial
失效
用于治疗中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症的2-吡啶酮衍生物
- 专利标题： 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial
- 专利标题（中）： 用于治疗中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症的2-吡啶酮衍生物
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申请号： US12299879申请日： 2007-05-07
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公开(公告)号： US07998984B2公开(公告)日： 2011-08-16
- 发明人: Peter Hansen , Karolina Lawitz , Matti Lepistö , Hans Lönn , Asim Ray
- 申请人： Peter Hansen , Karolina Lawitz , Matti Lepistö , Hans Lönn , Asim Ray
- 申请人地址： SE Södertälje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Södertälje
- 代理机构： Connolly Bove Lodge & Hutz LLP
- 国际申请： PCT/SE2007/000441 WO 20070507
- 国际公布： WO2007/129962 WO 20071115
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/47 ; C07D413/00 ; C07D401/00
摘要：
The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
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