发明授权
US08012966B2 Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors
有权
吡咯并[3,2-c]吡啶-4-酮2-二氢吲哚酮蛋白激酶抑制剂
![Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors](/docs/US/2011-09-06/US08012966B2/abs.jpg.600x600.jpg)
- 专利标题： Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors
- 专利标题（中）： 吡咯并[3,2-c]吡啶-4-酮2-二氢吲哚酮蛋白激酶抑制剂
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申请号： US12223180申请日： 2007-01-24
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公开(公告)号： US08012966B2公开(公告)日： 2011-09-06
- 发明人: Peng Cho Tang , Yidong Su , Lei Zhang , Lu Xiao
- 申请人： Peng Cho Tang , Yidong Su , Lei Zhang , Lu Xiao
- 申请人地址： CN Shanghai
- 专利权人： Shanghai Hengrui Pharmaceutical Co., Ltd.
- 当前专利权人： Shanghai Hengrui Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Shanghai
- 代理机构： Rothwell, Figg, Ernst & Manbeck PC
- 优先权： CN200610003229 20060127; CN200610065001 20060315; CN200610122000 20060830
- 国际申请： PCT/CN2007/000256 WO 20070124
- 国际公布： WO2007/085188 WO 20070802
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/519 ; A61K31/5377 ; C07D471/04 ; C07D487/04 ; C07D413/14 ; A61P35/00
![Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors](/abs-image/US/2011/09/06/US08012966B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinone compounds of Formula (I) and their pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8X, Y and have the meaning cited in the specification. Also disclosed are the pharmaceutical compositions containing the foregoing compounds, methods for the preparation and pharmaceutical use thereof, particularly as protein kinase inhibitors. Formula (I).
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