Invention Grant
- Patent Title: Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same
- Patent Title (中): 分子间相互作用的腔诱导变构修饰和识别影响相同的化合物的方法
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Application No.: US12632221Application Date: 2009-12-07
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Publication No.: US08019557B2Publication Date: 2011-09-13
- Inventor: Ramachandran Murali , Mark I. Greene
- Applicant: Ramachandran Murali , Mark I. Greene
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Woodcock Washburn, LLP
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G01N33/566 ; A61K38/00 ; C07K1/00
Abstract:
Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
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