发明授权
- 专利标题： 6-modified bicyclic nucleic acid analogs
- 专利标题（中）： 6-修饰的双环核酸类似物
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申请号： US12774527申请日： 2010-05-05
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公开(公告)号： US08022193B2公开(公告)日： 2011-09-20
- 发明人: Punit P. Seth , Eric E. Swayze
- 申请人： Punit P. Seth , Eric E. Swayze
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Jones Day
- 主分类号： C07H19/00
- IPC分类号： C07H19/00 ; C07H21/00
摘要：
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
公开/授权文献
- US20100216979A1 6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS 公开/授权日：2010-08-26
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