Invention Grant
US08030488B2 Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents
有权
哌嗪衍生物作为硬脂酰辅酶A去饱和酶抑制剂及其作为治疗剂的用途
- Patent Title: Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents
- Patent Title (中): 哌嗪衍生物作为硬脂酰辅酶A去饱和酶抑制剂及其作为治疗剂的用途
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Application No.: US12247792Application Date: 2008-10-08
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Publication No.: US08030488B2Publication Date: 2011-10-04
- Inventor: Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
- Applicant: Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
- Applicant Address: CA Burnaby, BC
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby, BC
- Agency: Seed IP Law Group PLLC
- Main IPC: C07D239/02
- IPC: C07D239/02
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Public/Granted literature
- US20090030008A1 PIPERAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Public/Granted day:2009-01-29
Information query
