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1.发明授权Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents 有权哌嗪衍生物作为硬脂酰辅酶A去饱和酶抑制剂及其作为治疗剂的用途公开(公告)号：US08030488B2
公开(公告)日：2011-10-04
申请号：US12247792
申请日：2008-10-08
申请人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
发明人： Serguei Sviridov , Vishnumurthy Kodumuru , Shifeng Liu , Melwyn Abreo , Michael D. Winther , Heinz W. Gschwend , Rajender Kamboj , Shaoyi Sun , Mark W. Holladay , Wenbao Li , Chi Tu
IPC分类号： C07D239/02
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中G，J，L，M，x ，Y，W，V，R2，R3，R4，R5，R6，R7，R8，R8a，R9，R9a，R10，R10a，R11和R11a。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07763618B2
公开(公告)日：2010-07-27
申请号：US10566857
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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3.发明申请公开(公告)号：US20090197894A1
公开(公告)日：2009-08-06
申请号：US12423432
申请日：2009-04-14
申请人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
发明人： Jian-Min Fu , Vishnumurthy Kodumuru , Shaoyi Sun , Michael D. Winther , Richard M. Fine , Daniel F. Harvey , Boris Klebansky , Mark P. Gray-Keller , Heinz W. Gschwend , Wenbao Li
IPC分类号： A61K31/496 , C07D401/04 , A61P3/10
CPC分类号： A61K31/496 , A61K31/551 , Y02A50/387
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中m，n，p，V，R ，R2，R3，R4，R5和R6如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20090131447A1
公开(公告)日：2009-05-21
申请号：US11815739
申请日：2006-02-08
申请人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
发明人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
IPC分类号： A61K31/501 , A61K31/4436 , A61K31/496 , A61P3/04
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物治疗组合以治疗不利的体重增加。
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5.发明授权Recombinant DNA expression vector encoding for foot and mouth disease virus proteins 失效编码口蹄疫病毒蛋白的重组DNA表达载体
公开(公告)号：US4743554A
公开(公告)日：1988-05-10
申请号：US728464
申请日：1985-05-01
申请人： John C. Boothroyd , George A. M. Cross , Michael D. Highfield , Michael D. Winther , David J. Rowlands , Fred Brown , Timothy J. R. Harris
发明人： John C. Boothroyd , George A. M. Cross , Michael D. Highfield , Michael D. Winther , David J. Rowlands , Fred Brown , Timothy J. R. Harris
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/32122 , Y10S930/222
摘要： A DNA molecule comprising a nucleotide sequence substantially corresponding to all or a portion of foot and mouth disease virus RNA and in particular coding for at least one protein of foot and mouth disease virus. The DNA molecule can be inserted into a DNA cloning vehicle capable of expressing the DNA molecule, after a suitable host cell has been transformed by the cloning vehicle. The expression product can be incorporated into a vaccine for stimulating antibodies against FMDV. Methods for producing the DNA molecule, recombinant cloning vehicle and transformed host cell are described.
摘要翻译： DNA分子，其包含基本上对应于口蹄疫病毒RNA的全部或部分的核苷酸序列，特别是编码至少一种口蹄疫病毒蛋白质。 在通过克隆载体转化合适的宿主细胞后，可以将DNA分子插入能够表达DNA分子的DNA克隆载体中。 表达产物可以并入用于刺激针对FMDV的抗体的疫苗中。 描述了生产DNA分子，重组克隆载体和转化的宿主细胞的方法。
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公开(公告)号：US08383628B2
公开(公告)日：2013-02-26
申请号：US12816076
申请日：2010-06-15
申请人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07759348B2
公开(公告)日：2010-07-20
申请号：US12036685
申请日：2008-02-25
IPC分类号： A61K31/497 , C07D403/14 , C07D403/04
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D473/00
摘要： Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human include administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein.
摘要翻译： 在哺乳动物，优选人中治疗SCD介导的皮肤病症或病症的方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 2，R 3，R 4，R 5 ，R6，R6a，R7，R7a，R8，R8a，R9和R9a如本文所定义。
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公开(公告)号：US07754711B2
公开(公告)日：2010-07-13
申请号：US11055034
申请日：2005-02-09
申请人： Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael D. Winther , Zaihui Zhang , Melwyn Abreo , Mark W. Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz W. Gschwend
发明人： Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael D. Winther , Zaihui Zhang , Melwyn Abreo , Mark W. Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz W. Gschwend
IPC分类号： A61K31/551 , A61K31/5513 , A61K31/50 , A61K31/502 , A61K31/501 , C07D245/02 , C07D243/04 , C07D243/08 , C07D403/04 , C07D401/14 , C07D403/14 , A61P7/12
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了治疗哺乳动物，优选人类的SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（Ia）化合物：其中x，y，W，V，R 2 ，R3，R4，R5，R6，R6a，R7，R7a，R8，R8a，R9和R9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20100048584A1
公开(公告)日：2010-02-25
申请号：US12552868
申请日：2009-09-02
申请人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/496 , C12N9/99 , A61P3/04 , A61P3/00 , C07D401/04 , C07D401/14
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07605161B2
公开(公告)日：2009-10-20
申请号：US10566193
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中：W是-O - ， - N （R 1） - ，C（O），S（O）t; （其中t为0,1或2），N（R1）S（O）2，S（O）2N（R1），C（O）N（R1）或N（R1）C（O） ）; 并且V是C（O），C（S），C（O）N（R 1） - ，C（O）O-，S（O）2 - ，S（O）2 N（R 1） - 或C ）H; 并且x，y，R1，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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