Disclosed are example open channel detection techniques at a light emitting diode (LED) driver of an LED system. The LED driver does not enable its LED channels before normal operation so as to inhibit current flow through the LED channels during start-up. While the LED channels are disabled, the LED driver compares the voltages at the LED channel inputs with a predetermined voltage to determine whether an operational LED string of an associated LED panel is connected to the LED channel. In the event that an LED channel is determined to be an “open” channel, the LED driver further disables the LED channel for the following normal operational mode. Otherwise, if the LED channel is determined to be connected to an operational LED string, the LED driver enables the LED channel for the normal operational mode, during which the LED channel can be selectively activated for light output subject to display data for the LED panel.