发明授权
- 专利标题: Heteroaryloxy nitrogenous saturated heterocyclic derivative
- 专利标题(中): 杂环氧基含氮饱和杂环衍生物
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申请号: US12540534申请日: 2009-08-13
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公开(公告)号: US08044070B2公开(公告)日: 2011-10-25
- 发明人: Norikazu Ohtake , Akira Naya , Yuji Haga , Makoto Jitsuoka , Takuya Suga , Ryo Yoshimoto , Shigeru Tokita , Akio Kanatani
- 申请人: Norikazu Ohtake , Akira Naya , Yuji Haga , Makoto Jitsuoka , Takuya Suga , Ryo Yoshimoto , Shigeru Tokita , Akio Kanatani
- 申请人地址: JP Chiyoda-ku
- 专利权人: MSD K.K.
- 当前专利权人: MSD K.K.
- 当前专利权人地址: JP Chiyoda-ku
- 代理商 J. Eric Thies; Gerard M. Devlin
- 优先权: JP2003-184879 20030627
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; C07D211/00
摘要:
Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): or the following formula (III): Y represents a group of a formula (IV): The compounds have a histamine-H3 receptor antagonistic or inverse-agonistic activity and are useful for remedy and/or prevention of obesity, diabetes, hormone secretion disorders, sleep disorders, etc.