发明授权
US08048897B2 Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
有权
环己烷衍生物,其前药及其盐,以及含有其的用于糖尿病的治疗剂
- 专利标题: Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
- 专利标题(中): 环己烷衍生物,其前药及其盐,以及含有其的用于糖尿病的治疗剂
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申请号: US11658400申请日: 2005-07-26
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公开(公告)号: US08048897B2公开(公告)日: 2011-11-01
- 发明人: Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
- 申请人: Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Nobuo Shimma
- 申请人地址: JP Tokyo
- 专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人: Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址: JP Tokyo
- 代理机构: Browdy and Neimark, PLLC
- 优先权: JP2004-217065 20040726; JP2004-340104 20041125
- 国际申请: PCT/JP2005/013634 WO 20050726
- 国际公布: WO2006/011469 WO 20060202
- 主分类号: A61K31/7028
- IPC分类号: A61K31/7028 ; A61K31/403 ; A61P3/10 ; C07C63/00 ; C07D209/04 ; C07D213/62 ; C07D231/14 ; C07D307/79 ; C07D317/48 ; C07D333/34 ; C07D333/56
摘要:
A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.
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