发明授权
- 专利标题： HMGB1 high affinity binding domain Box-A mutants
- 专利标题（中）： HMGB1高亲和力结合域Box-A突变体
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申请号： US12614805申请日： 2009-11-09
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公开(公告)号： US08058232B2公开(公告)日： 2011-11-15
- 发明人: Silvano Fumero , Luisa Bertarione Rava Rossa , Domenico G. Barone , Lila Drittanti , Thierry Guyon , Gilles Borrelly , Barbara Canepa , Chiara Lorenzetto
- 申请人： Silvano Fumero , Luisa Bertarione Rava Rossa , Domenico G. Barone , Lila Drittanti , Thierry Guyon , Gilles Borrelly , Barbara Canepa , Chiara Lorenzetto
- 申请人地址： IT Colleretto Giacosa
- 专利权人： Creabilis Therapeutics S.p.A.
- 当前专利权人： Creabilis Therapeutics S.p.A.
- 当前专利权人地址： IT Colleretto Giacosa
- 代理机构： Rothwell, Figg, Ernst & Manbeck, P.C.
- 优先权： EP04425665 20040903
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/47 ; C12N15/00 ; C12P21/02
摘要：
The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favorable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.
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