发明授权
- 专利标题: Methods for cancer therapy and stem cell modulation
- 专利标题(中): 癌症治疗和干细胞调节方法
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申请号: US12281470申请日: 2006-11-15
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公开(公告)号: US08058258B2公开(公告)日: 2011-11-15
- 发明人: Qiang Yu , Jing Tan , Xiao Jing Yang
- 申请人: Qiang Yu , Jing Tan , Xiao Jing Yang
- 申请人地址: SG Centros
- 专利权人: Agency for Science, Technology and Research
- 当前专利权人: Agency for Science, Technology and Research
- 当前专利权人地址: SG Centros
- 代理机构: Choate, Hall & Stewart, LLP
- 国际申请: PCT/SG2006/000350 WO 20061115
- 国际公布: WO2007/100304 WO 20070907
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70
摘要:
The present invention relates to a method of inducing apoptosis in a tumour cell as well as modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of general formula (I). In general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen, such as F or Cl. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a pharmaceutical composition for inducing apoptosis in a tumour cell and/or modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The pharmaceutical composition comprises a compound as defined above or a pharmaceutically acceptable salt thereof and a carrier or diluent.
公开/授权文献
- US20100075915A1 METHODS FOR CANCER THERAPY AND STEM CELL MODULATION 公开/授权日:2010-03-25