发明授权
US08062887B2 Monoclonal antibody specifically recognizing modification site after translation of p53 and kit for assaying modification site containing the same
有权
特异性识别p53翻译后的修饰位点的单克隆抗体和用于测定含有该修饰位点的试剂盒
- 专利标题： Monoclonal antibody specifically recognizing modification site after translation of p53 and kit for assaying modification site containing the same
- 专利标题（中）： 特异性识别p53翻译后的修饰位点的单克隆抗体和用于测定含有该修饰位点的试剂盒
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申请号： US11910313申请日： 2006-03-31
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公开(公告)号： US08062887B2公开(公告)日： 2011-11-22
- 发明人: Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutsumi
- 申请人： Kazuyasu Sakaguchi , Yoshiro Chuman , Yasuo Akebiyama , Miho Matsukizono , Maki Watanabe , Junichi Tsutsumi
- 申请人地址： JP Sapporo-Shi Hokkaido JP Fukuoka
- 专利权人： National University Corporation, Hokkaido University,Genenet Co., Ltd.
- 当前专利权人： National University Corporation, Hokkaido University,Genenet Co., Ltd.
- 当前专利权人地址： JP Sapporo-Shi Hokkaido JP Fukuoka
- 代理机构： Fulbright & Jaworski L.L.P.
- 优先权： JP2005-106130 20050401
- 国际申请： PCT/JP2006/306921 WO 20060331
- 国际公布： WO2006/106957 WO 20061012
- 主分类号： C12N5/12
- IPC分类号： C12N5/12 ; C07K16/18
摘要：
The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.
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