公开(公告)号：US08062887B2

公开(公告)日：2011-11-22

申请号：US11910313

申请日：2006-03-31

申请人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutsumi

发明人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutsumi

IPC分类号： C12N5/12 ,  C07K16/18

CPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  G01N33/5748 ,  G01N2333/4748

摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.

摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。

公开(公告)号：US20090298700A1

公开(公告)日：2009-12-03

申请号：US11910313

申请日：2006-03-31

申请人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutumi

发明人： Kazuyasu Sakaguchi ,  Yoshiro Chuman ,  Yasuo Akebiyama ,  Miho Matsukizono ,  Maki Watanabe ,  Junichi Tsutumi

IPC分类号： C40B30/00 ,  C07K16/00 ,  C12N5/06 ,  C40B40/10

CPC分类号： C07K16/18 ,  C07K7/06 ,  C07K7/08 ,  G01N33/5748 ,  G01N2333/4748

摘要： The present invention provides a monoclonal antibody recognizing modification after translation of p53 in a manner specific to a modification site, an antibody microarray comprising the antibody immobilized on a substrate, etc. Disclosed is a monoclonal antibody which reacts specifically with a peptide consisting of an amino acid sequence of at least 6 consecutive amino acids containing a predetermined amino acid residue of the amino acid sequence represented by SEQ ID NO: 1, wherein the amino acid residue is phosphorylated or acetylated, or with a peptide having one to several arbitrary amino acids added to the above peptide, but does not react with the above peptide which is not phosphorylated or acetylated.

摘要翻译： 本发明提供了以对修饰位点特异性的方式翻译p53后的单克隆抗体，包含固定在底物上的抗体的抗体微阵列等。公开了与由氨基组成的肽特异性反应的单克隆抗体 含有由SEQ ID NO：1表示的氨基酸序列的预定氨基酸残基的至少6个连续氨基酸的酸序列，其中所述氨基酸残基被磷酸化或乙酰化，或者与具有一至几个任意氨基酸的肽相加 但不与未被磷酸化或乙酰化的上述肽反应。