发明授权
- 专利标题： Inhibitors of syk and JAK protein kinases
- 专利标题（中）： syk和JAK蛋白激酶抑制剂
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申请号： US12386525申请日： 2009-04-16
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公开(公告)号： US08063058B2公开(公告)日： 2011-11-22
- 发明人: Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
- 申请人： Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
- 申请人地址： US CA South San Francisco
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： A01N43/54
- IPC分类号： A01N43/54 ; A61K31/505 ; C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D411/00 ; C07D413/00 ; C07D417/00 ; C07D419/00
摘要：
The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
公开/授权文献
- US20100048567A1 Inhibitors of syk and JAK protein kinases 公开/授权日：2010-02-25
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