发明授权
US08063222B2 Aryl sulfonamides useful as inhibitors of chemokine receptor activity
失效
用作趋化因子受体活性抑制剂的芳基磺酰胺
- 专利标题： Aryl sulfonamides useful as inhibitors of chemokine receptor activity
- 专利标题（中）： 用作趋化因子受体活性抑制剂的芳基磺酰胺
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申请号： US12229818申请日： 2008-08-27
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公开(公告)号： US08063222B2公开(公告)日： 2011-11-22
- 发明人: Mingshi Dai , Bing Guan , Robert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles A. Minor , Tracy J. Jenkins
- 申请人： Mingshi Dai , Bing Guan , Robert A. Bennett , Douglas F. Burdi , Shomir Ghosh , Gang Li , Charles A. Minor , Tracy J. Jenkins
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07D215/38
- IPC分类号： C07D215/38
摘要：
The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X1, Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
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