发明授权
US08071612B2 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
有权
6-烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂
- 专利标题： 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
- 专利标题（中）： 6-烯基和6-苯基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂
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申请号： US12950345申请日： 2010-11-19
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公开(公告)号： US08071612B2公开(公告)日： 2011-12-06
- 发明人: Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- 申请人： Dominique Jean-Pierre Mabire , Jérôme Emile Georges Guillemont , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- 申请人地址： BE
- 专利权人： Janssen Pharmaceutica, NV
- 当前专利权人： Janssen Pharmaceutica, NV
- 当前专利权人地址： BE
- 优先权： EP04819601 20041118
- 主分类号： C07D221/12
- IPC分类号： C07D221/12
摘要：
The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and their use as PARP inhibitors wherein n, R1, R2, R3, R4, R5, R6, R7, Re, Rd and X have defined meanings.
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