发明授权
- 专利标题： Nucleic acid inhibitors of glutamate receptors
- 专利标题（中）： 谷氨酸受体的核酸抑制剂
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申请号： US12578231申请日： 2009-10-13
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公开(公告)号： US08076467B2公开(公告)日： 2011-12-13
- 发明人: Li Niu , Zhen Huang , Hua Shi , John T. Lis
- 申请人： Li Niu , Zhen Huang , Hua Shi , John T. Lis
- 申请人地址： US NY Albany US NY Ithaca
- 专利权人： The Research Foundation of State University of New York,Cornell University
- 当前专利权人： The Research Foundation of State University of New York,Cornell University
- 当前专利权人地址： US NY Albany US NY Ithaca
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 代理商 Kathy Smith Dias
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/04 ; C40B40/06 ; C40B40/00 ; C40B50/00 ; C40B30/00 ; A61K48/00
摘要：
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
公开/授权文献
- US20100099749A1 Nucleic Acid Inhibitors Of Glutamate Receptors 公开/授权日：2010-04-22
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