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    Electrophoretic chip for electrophoretic applications
    1.
    发明授权
    Electrophoretic chip for electrophoretic applications 有权

    公开(公告)号：US11609472B2

    公开(公告)日：2023-03-21

    申请号：US16473108

    申请日：2017-12-28

    申请人： ADOR DIAGNOSTICS S.R.L.

    发明人： Dalibor Hodko ,  Howard R. Reese ,  Vladimir Hurgin

    IPC分类号： G02F1/167 ,  C40B30/10 ,  B01L3/00 ,  C12N15/10 ,  B01L7/00 ,  C12M1/00 ,  C40B40/00

    摘要： The present invention discloses an electrophoretic chip comprising: (a) a non-conductive substrate designed to support elements of said electrophoretic chip; (b) an electrode structure for conducting current through said electrophoretic chip, printed on said non-conductive substrate and comprising a counter electrode and at least one working electrode, each electrode comprising a conductive low-resistance ink layer printed on the non-conductive substrate, and a carbon ink layer printed on top of and fully or partially covering said conductive low-resistance ink layer; (c) a dielectric ink insulator layer placed on top of, and covering, said electrode structure, said dielectric ink insulator layer having at least one opening above the counter electrode and at least one opening above said at least one working electrode, thereby forming at least one addressable location; and (d) a molecule capturing matrix spotted on and covering said at least one addressable location, thereby creating at least one microgel region.

    Multiplexed analyses of test samples
    5.
    发明授权
    Multiplexed analyses of test samples 有权

    公开(公告)号：US10422794B2

    公开(公告)日：2019-09-24

    申请号：US14569241

    申请日：2014-12-12

    申请人： SomaLogic, Inc.

    发明人： James R. Heil ,  Daniel J. Schneider ,  Daniel T. Nieuwlandt ,  Sheri K. Wilcox ,  Dominic Zichi ,  Todd Gander ,  Bruce Eaton ,  Larry Gold

    IPC分类号： G01N33/543 ,  C12Q1/6832 ,  C12Q1/6834 ,  C12Q1/6837 ,  G01N33/58 ,  C40B40/00

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art.

    Multiplexed Analyses of Test Samples
    7.
    发明申请
    Multiplexed Analyses of Test Samples 审中-公开

    公开(公告)号：US20180156787A1

    公开(公告)日：2018-06-07

    申请号：US15878021

    申请日：2018-01-23

    申请人： SomaLogic, Inc.

    发明人： James R. Heil ,  Daniel J. Schneider ,  Daniel T. Nieuwlandt ,  Sheri K. Wilcox ,  Dominic Zichi ,  Todd Gander ,  Bruce Eaton ,  Larry Gold

    IPC分类号： G01N33/543 ,  G01N33/58 ,  C12Q1/6837 ,  C12Q1/6832 ,  C12Q1/6834 ,  C40B40/00

    摘要： The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. An aptamer affinity complex that includes an aptamer bound to its target molecule is allowed to form. If the test sample contains the target molecule, an aptamer affinity complex will generally form in the test sample. The aptamer affinity complex is optionally converted to an aptamer covalent complex that includes an aptamer covalently bound to its target molecule. The aptamer affinity complex (or optional aptamer covalent complex) can then be detected and/or quantified using any of a variety of methods known to one skilled in the art, including using a solid support, using mass spectrometry, and using quantitative polymerase chain reaction (Q-PCR).

    Efficient oriP/EBNA-1 plasmid vector
    9.
    发明授权
    Efficient oriP/EBNA-1 plasmid vector 有权
    高效的oriP / EBNA-1质粒载体

    公开(公告)号：US09206439B2

    公开(公告)日：2015-12-08

    申请号：US12353835

    申请日：2009-01-14

    申请人： Scott Eugene Lindner ,  William M. Sugden

    发明人： Scott Eugene Lindner ,  William M. Sugden

    IPC分类号： C12N15/00 ,  C07H21/02 ,  G01N33/00 ,  C40B40/00 ,  C12N5/07 ,  A01N63/00 ,  C12N15/85

    CPC分类号： C12N15/85 ,  C12N2710/16222 ,  C12N2820/60

    摘要： The invention provides a recombinant vector comprising a DNA segment having a synthetic origin of DNA synthesis that binds EBNA-1 and is capable of initiating DNA synthesis of sequences linked to the synthetic origin of DNA synthesis and maintaining the linked sequences when in the presence of EBNA-1. The synthetic origin of DNA synthesis comprises at least two binding sites for EBNA-1, wherein the two EBNA-1 binding sites are flanked by at least two half-binding sites for TRF2 or at least two binding sites for a protein that enhances the affinity of EBNA-1 for the synthetic origin of DNA synthesis. Further provided are host cells with the vector and methods of using the vector, for instance, ex vivo or in vivo.

    摘要翻译： 本发明提供一种重组载体，其包含具有结合EBNA-1的合成DNA合成起点的DNA区段，并且能够启动与合成DNA合成起始点连接的序列的DNA合成并在EBNA存在时维持连接序列 -1。 DNA合成的合成起点包含至少两个EBNA-1的结合位点，其中两个EBNA-1结合位点侧接于TRF2的至少两个半结合位点或增强亲和力的蛋白质的至少两个结合位点 的EBNA-1用于DNA合成的合成来源。 还提供了具有载体的宿主细胞和使用载体的方法，例如离体或体内。