Invention Grant
- Patent Title: Process for the manufacture of epoxy triazole derivatives
- Patent Title (中): 制备环氧三唑衍生物的方法
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Application No.: US12872599Application Date: 2010-08-31
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Publication No.: US08076494B2Publication Date: 2011-12-13
- Inventor: Marc Muller , Lin Xu
- Applicant: Marc Muller , Lin Xu
- Applicant Address: CH Basel
- Assignee: Basilea Pharmaceutica AG
- Current Assignee: Basilea Pharmaceutica AG
- Current Assignee Address: CH Basel
- Priority: EP05026163 20051201
- Main IPC: C07D309/12
- IPC: C07D309/12 ; C07D319/06 ; C07C49/225 ; C07C49/233 ; C07F7/18

Abstract:
Disclosed is a process for the manufacture of a compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which process a compound of formula (II) is converted to a corresponding alkyl, fluoroalkyl or aryl sulfonic acid ester, which is then reacted with an alkali metal nitrite in the presence of a suitable crown ether in a polar non-nucleophilic solvent at a temperature of −10 to 50° C. to give the compound of formula (I).
Public/Granted literature
- US20110021794A1 Process for the manufacture of epoxy triazole derivatives Public/Granted day:2011-01-27
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