发明授权
US08084027B2 Combinations comprising a CDK inhibitor and a growth factor antibody or anti-mitotic
有权
包含CDK抑制剂和生长因子抗体或抗有丝分裂的组合
- 专利标题： Combinations comprising a CDK inhibitor and a growth factor antibody or anti-mitotic
- 专利标题（中）： 包含CDK抑制剂和生长因子抗体或抗有丝分裂的组合
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申请号： US12278530申请日： 2007-02-02
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公开(公告)号： US08084027B2公开(公告)日： 2011-12-27
- 发明人: Ciro Mercurio , Enrico Pesenti , Maria Grazia Porro , Paolo Pevarello
- 申请人： Ciro Mercurio , Enrico Pesenti , Maria Grazia Porro , Paolo Pevarello
- 申请人地址： IT Nerviano
- 专利权人： Nerviano Medical Sciences S.r.l.
- 当前专利权人： Nerviano Medical Sciences S.r.l.
- 当前专利权人地址： IT Nerviano
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 优先权： EP06101523 20060210
- 国际申请： PCT/EP2007/051020 WO 20070202
- 国际公布： WO2007/090794 WO 20070816
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides a combination comprising a compound A of formula (I) as set forth in the specification or a pharmaceutically acceptable salt thereof, and an antibody inhibiting a growth factor or its receptor and/or an antimitotic agent or a derivative or prodrug thereof, useful in the treatment of tumors. The chemical name of compound A is 8-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide.
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