A polyp trap for use in collecting tissue samples. The device includes a collection container and a removable tray. The collection container has an inlet port, a sidewall aperture, and an exit port. The removable tray has a first end and a second end. The tray is sized for movement within the sidewall aperture between an inserted position forming a seal with the collection container and a withdrawn position remote from the collection container. The tray has a perforated bottom surface such that fluids traveling under suction from the inlet port to the outlet port pass through the tray.