Invention Grant
- Patent Title: Indazoles as glucocorticoid receptor ligands
- Patent Title (中): 吲哚类作为糖皮质激素受体配体
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Application No.: US11910935Application Date: 2006-04-12
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Publication No.: US08093281B2Publication Date: 2012-01-10
- Inventor: Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
- Applicant: Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Robert J. Smith
- Priority: GB0507597.3 20050414; GB0516375.3 20050809; GB0522882.0 20051109
- International Application: PCT/EP2006/003551 WO 20060412
- International Announcement: WO2006/108699 WO 20061019
- Main IPC: A61K31/416
- IPC: A61K31/416 ; C07D231/56

Abstract:
A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
Public/Granted literature
- US20090074675A1 INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS Public/Granted day:2009-03-19
Information query
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