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21 条记录 (耗时 0.032 秒)

    Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents
    9.
    发明申请
    Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents 审中-公开
    吡唑并嘧啶衍生物作为抗炎剂

    公开(公告)号：US20080292561A1

    公开(公告)日：2008-11-27

    申请号：US12092974

    申请日：2006-11-07

    申请人： Keith Biggadike ,  David House ,  Graham George Adam Inglis ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone

    发明人： Keith Biggadike ,  David House ,  Graham George Adam Inglis ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone

    IPC分类号： A61K9/12 ,  C07D487/04 ,  A61P17/00 ,  A61K31/519

    CPC分类号： C07D487/04

    摘要： A compound of formula (I): is claimed wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; R1 represents phenyl, pyridyl or thienyl wherein the phenyl group may be optionally substituted by one or two groups independently selected from fluorine, cyano, —C(O)OCH3 and —C(O)OCH2CH3, and the pyridyl group may be optionally substituted by one fluorine group; and R2 represents methyl or ethyl; along with physiologically functional derivatives thereof, pharmaceutical compositions and formulations thereof, combinations thereof, methods of treatment employing such compounds and processes for preparing the compounds.

    摘要翻译： 要求的式（I）化合物：其中A代表2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; R 1表示苯基，吡啶基或噻吩基，其中苯基可以任选地被一个或两个独立地选自氟，氰基，-C（O）OCH 3和-C（O）OCH 2 CH 3的基团取代，并且吡啶基可以任选地被 一氟类; R2代表甲基或乙基; 以及其生理功能衍生物，药物组合物及其制剂，其组合，使用这些化合物的治疗方法和制备该化合物的方法。