Invention Grant
US08097254B2 Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
有权
用于闪烁扫描的特异性结合分子，含有它们的缀合物和用于治疗血管发生的治疗方法
- Patent Title: Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
- Patent Title (中): 用于闪烁扫描的特异性结合分子，含有它们的缀合物和用于治疗血管发生的治疗方法
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Application No.: US10821930Application Date: 2004-04-12
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Publication No.: US08097254B2Publication Date: 2012-01-17
- Inventor: Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
- Applicant: Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
- Applicant Address: CH Zurich
- Assignee: Eidgenossische Technische Hochschule Zurich
- Current Assignee: Eidgenossische Technische Hochschule Zurich
- Current Assignee Address: CH Zurich
- Agency: Millen, White, Zelano, Branigan, P.C.
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61K51/00 ; A61K38/39 ; C07K14/515
Abstract:
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
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