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1.发明申请Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis 有权用于闪烁扫描的特异性结合分子，含有它们的缀合物和用于治疗血管发生的治疗方法公开(公告)号：US20060133994A1
公开(公告)日：2006-06-22
申请号：US10821930
申请日：2004-04-12
申请人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
发明人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
IPC分类号： A61K51/00 , A61K39/395 , C07K16/18
CPC分类号： C07C63/04 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/622
摘要： The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
摘要翻译： 本发明涉及对纤连蛋白的ED-B结构域的特征性表位具有亚纳摩尔亲和力的抗体，血管发生的标志物。 此外，它涉及放射性标记的高亲和力抗ED-B抗体用于检测体内新形成血管的用途，以及包含所述抗体的诊断试剂盒。 此外，它涉及包含所述抗体和合适的光活性分子（例如适当选择的光敏剂或放射性核素）的缀合物，以及它们用于选择性光介导的新血管阻塞的用途。
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公开(公告)号：US20120015033A1
公开(公告)日：2012-01-19
申请号：US13129205
申请日：2009-11-13
IPC分类号： A61K9/32 , A61K9/28 , A61P1/00 , A61K31/711
CPC分类号： C12N15/1136 , A61K9/0053 , A61K9/2846 , A61K31/7105 , A61K31/7125 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations can be used to treat Crohn's disease, ulcerative colitis and chronic inflammatory bowel disease.
摘要翻译： 本发明提供了用于口服给予反义寡核苷酸的药物制剂，例如针对SMAD7的反义寡核苷酸。 药物制剂可用于治疗克罗恩病，溃疡性结肠炎和慢性炎症性肠病。
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公开(公告)号：US06495673B1
公开(公告)日：2002-12-17
申请号：US09699931
申请日：2000-10-30
申请人： Dario Neri , Salvatore Demartis , Adrian Huber , Francesca Viti , Dan S Tawfik , Gregory Paul Winter
发明人： Dario Neri , Salvatore Demartis , Adrian Huber , Francesca Viti , Dan S Tawfik , Gregory Paul Winter
IPC分类号： C07H2100
CPC分类号： C12N15/1086 , C07K14/4728 , C07K14/72 , C07K2319/00 , C12N9/00 , C12N9/0002 , C12N9/1088 , C12N9/1205 , C12N15/1037 , C40B40/02
摘要： A method for isolating the DNA encoding an enzyme is presented. The DNA is contained within a support to which the enzyme is linked, wherein the enzyme is further linked to a substrate. When the enzyme reacts with the substrate, the product remains linked to the enzyme. The product linked to the enzyme which is linked to the support containing the DNA encoding the enzyme is isolated, thereby isolating the DNA encoding the enzyme. In this manner an expression library of enzymes produced by mutagenesis can be screened for mutated active enzyme, and thereby obtain the mutated DNA encoding the mutated active enzyme.
摘要翻译： 提出了分离编码酶的DNA的方法。 DNA包含在与酶连接的载体内，其中酶进一步连接到底物上。 当酶与底物反应时，产物保持与酶连接。 分离与连接到含有编码该酶的DNA的载体连接的酶的产物，从而分离编码该酶的DNA。 以这种方式，可通过诱变产生的酶的表达文库筛选突变的活性酶，从而获得编码突变的活性酶的突变的DNA。
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公开(公告)号：US20150148245A1
公开(公告)日：2015-05-28
申请号：US14344969
申请日：2012-09-14
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , G01N33/505 , G01N33/5094 , G01N33/6866 , G01N33/6869 , G01N33/6872 , G01N2333/54 , G01N2333/7158 , G01N2800/065 , G01N2800/52
摘要： Methods for monitoring whether a subject will be sensitive or resistant to treatment with an anti-SMAD7 therapy are disclosed. The methods are based on the determining of the amount of CCR9+ FOXP3+ T cells, CCR9+ IFN-gamma+ T cells, CCR9+ IL17A+ T cells, FOXP3+ T cells, IFN-gamma+ T cells, and/or IL17A+ T cells in a sample from the subject. Measurement of T cell populations may be determined by flow cytometry, immunohistochemistry, and/or ELISA.
摘要翻译： 公开了用于监测受试者是否对抗SMAD7治疗敏感或抗药性的方法。 该方法基于来自受试者的样品中CCR9 + FOXP3 + T细胞，CCR9 + IFN-γ+ T细胞，CCR9 + IL17A + T细胞，FOXP3 + T细胞，IFN-γ+ T细胞和/或IL17A + T细胞的量的测定 。 T细胞群的测定可以通过流式细胞术，免疫组化和/或ELISA来测定。
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公开(公告)号：US08501806B2
公开(公告)日：2013-08-06
申请号：US13131982
申请日：2009-12-03
IPC分类号： A61K31/19
CPC分类号： A61K31/196 , A61K9/0014 , A61K31/136 , A61K31/166 , A61K31/343 , A61K31/357
摘要： The present invention is directed in part to methods of preventing or reducing colon carcinogenesis comprising administering to a patient at risk of colorectal cancer, a pharmaceutical preparation comprising a chemopreventive agent disclosed herein.
摘要翻译： 本发明部分地涉及预防或减少结肠癌发生的方法，其包括向具有结肠直肠癌风险的患者施用包含本文公开的化学预防剂的药物制剂。
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公开(公告)号：US20120053244A1
公开(公告)日：2012-03-01
申请号：US13201786
申请日：2010-02-16
IPC分类号： A61K31/196 , A61K8/44 , A61Q19/00 , A61P29/00 , A61P35/00 , A61P17/00 , A61P17/06 , A61P1/00 , C07C233/54 , A61Q19/08
CPC分类号： A61K31/196 , A61K8/42 , A61K2800/78 , A61Q5/00 , A61Q7/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07C233/54 , C07C235/38 , C07D307/79 , C07D319/08
摘要： Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.
摘要翻译： 本文公开了可以对PPAR和/或EGF受体特异的化合物，以及制备和使用它们的方法。
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7.发明授权Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis 有权用于闪烁扫描的特异性结合分子，含有它们的缀合物和用于治疗血管发生的治疗方法公开(公告)号：US08097254B2
公开(公告)日：2012-01-17
申请号：US10821930
申请日：2004-04-12
申请人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
发明人： Dario Neri , Lorenzo Tarli , Francesca Viti , Manfred Birchler
IPC分类号： A61K39/00 , A61K39/395 , A61K51/00 , A61K38/39 , C07K14/515
CPC分类号： C07C63/04 , A61K51/1018 , A61K2039/505 , C07K16/18 , C07K2317/622
摘要： The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
摘要翻译： 本发明涉及对纤连蛋白的ED-B结构域的特征性表位具有亚纳摩尔亲和力的抗体，血管发生的标志物。 此外，它涉及放射性标记的高亲和力抗ED-B抗体用于检测体内新形成血管的用途以及包含所述抗体的诊断试剂盒。 此外，它涉及包含所述抗体和合适的光活性分子（例如适当选择的光敏剂或放射性核素）的缀合物，以及它们用于选择性光介导的新血管阻塞的用途。
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公开(公告)号：US06184012B2
公开(公告)日：2001-02-06
申请号：US09142355
申请日：1999-04-22
申请人： Dario Neri , Salvatore Demartis , Adrian Huber , Francesca Viti , Dan S Tawfik , Gregory Paul Winter
发明人： Dario Neri , Salvatore Demartis , Adrian Huber , Francesca Viti , Dan S Tawfik , Gregory Paul Winter
IPC分类号： C12N990
CPC分类号： C12N15/1086 , C07K14/4728 , C07K14/72 , C07K2319/00 , C12N9/00 , C12N9/0002 , C12N9/1088 , C12N9/1205 , C12N15/1037 , C40B40/02
摘要： The present invention relates to a method of isolating an enzyme having a desired chemical or biological activity, the method comprising linking the enzyme to a substrate for the enzyme, reacting the enzyme and substrate such that a product is produced which remains linked to the enzyme and isolating the enzyme by selectively isolating the product linked to the enzyme.
摘要翻译： 本发明涉及一种分离具有所需化学或生物活性的酶的方法，该方法包括将酶与酶的底物连接，使酶和底物反应，使得产生与酶连接的产物， 通过选择性分离与酶连接的产物来分离酶。
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公开(公告)号：US09791442B2
公开(公告)日：2017-10-17
申请号：US14344969
申请日：2012-09-14
IPC分类号： G01N33/569 , G01N33/68 , G01N33/50
CPC分类号： G01N33/56972 , G01N33/505 , G01N33/5094 , G01N33/6866 , G01N33/6869 , G01N33/6872 , G01N2333/54 , G01N2333/7158 , G01N2800/065 , G01N2800/52
摘要： Methods for monitoring whether a subject will be sensitive or resistant to treatment with an anti-SMAD7 therapy are disclosed. The methods are based on the determining of the amount of CCR9+ FOXP3+ T cells, CCR9+ IFN-gamma+ T cells, CCR9+ IL17A+ T cells, FOXP3+ T cells, IFN-gamma+ T cells, and/or IL17A+ T cells in a sample from the subject. Measurement of T cell populations may be determined by flow cytometry, immunohistochemistry, and/or ELISA.
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公开(公告)号：US20150087708A1
公开(公告)日：2015-03-26
申请号：US14377362
申请日：2013-02-08
IPC分类号： C07C229/44
CPC分类号： C07C229/44 , A61K31/196 , A61K31/343 , A61K31/357
摘要： The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.
摘要翻译： 本公开部分地涉及治疗纤维化的方法，例如肝纤维化和/或肠纤维化，包括向有需要的患者施用有效量的所公开的化合物。
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