发明授权
- 专利标题： Compounds and compositions as protein kinase inhibitors
- 专利标题（中）： 化合物和组合物作为蛋白激酶抑制剂
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申请号： US11718886申请日： 2005-11-07
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公开(公告)号： US08101608B2公开(公告)日： 2012-01-24
- 发明人: Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
- 申请人： Yongqin Wan , Yuan Mi , Yi Fan , Dai Cheng , Yi Liu , Nathanael S. Gray , Pamela Albaugh
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC, a Delware Limited Corporation
- 当前专利权人： IRM LLC, a Delware Limited Corporation
- 当前专利权人地址： BM Hamilton
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Chihang Amy Smith
- 国际申请： PCT/US2005/040372 WO 20051107
- 国际公布： WO2006/052936 WO 20060518
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61K31/4025 ; A61K31/4178 ; A61K31/4245 ; A61K31/454 ; A61K31/5377 ; A61K31/496 ; C07D401/14 ; C07D403/14 ; C07D405/06 ; C07D405/14 ; C07D413/06 ; C07D413/14 ; C07D471/04
摘要：
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
公开/授权文献
- US20080221192A1 Compounds and Compositions as Protein Kinase Inhibitors 公开/授权日：2008-09-11
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