发明授权
US08101613B2 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
有权
6,6-双环取代杂双环蛋白激酶抑制剂
- 专利标题： 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
- 专利标题（中）： 6,6-双环取代杂双环蛋白激酶抑制剂
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申请号： US12540047申请日： 2009-08-12
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公开(公告)号： US08101613B2公开(公告)日： 2012-01-24
- 发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
- 申请人： Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
- 申请人地址： US NY Farmingdale
- 专利权人： OSI Pharmaceuticals, LLC
- 当前专利权人： OSI Pharmaceuticals, LLC
- 当前专利权人地址： US NY Farmingdale
- 主分类号： A01N43/58
- IPC分类号： A01N43/58 ; A01N43/60 ; A61K31/50 ; A61K31/495 ; C07D471/00 ; C07D487/00
摘要：
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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