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1.
公开(公告)号:US08101613B2
公开(公告)日:2012-01-24
申请号:US12540047
申请日:2009-08-12
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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2.
公开(公告)号:US07820662B2
公开(公告)日:2010-10-26
申请号:US12244947
申请日:2008-10-03
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: C07D487/00 , A01N43/64
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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3.
公开(公告)号:US08735405B2
公开(公告)日:2014-05-27
申请号:US13446629
申请日:2012-04-13
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew P. Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew P. Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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4.
公开(公告)号:US20120077979A1
公开(公告)日:2012-03-29
申请号:US13308694
申请日:2011-12-01
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D487/04 , C07F5/02
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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公开(公告)号:US20090118499A1
公开(公告)日:2009-05-07
申请号:US12244947
申请日:2008-10-03
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D487/04
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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公开(公告)号:US20120196847A1
公开(公告)日:2012-08-02
申请号:US13446629
申请日:2012-04-13
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/4985 , A61K31/53 , A61P35/00 , A61K31/5377 , A61K31/551 , C07D487/04 , A61K31/519
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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7.
公开(公告)号:US20090325928A1
公开(公告)日:2009-12-31
申请号:US12540047
申请日:2009-08-12
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D471/04 , A61K31/495 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/04
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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8.
公开(公告)号:US20060235031A1
公开(公告)日:2006-10-19
申请号:US11095162
申请日:2005-03-31
申请人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/52
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 下式的化合物及其药学上可接受的盐,其中X 1,X 2,X 3,X 4, X 5,X 6,X 7,R 1和Q 1 在本文中定义,抑制IGF-1R酶,并且可用于治疗和/或预防过度增殖性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢的疾病和状况 神经系统。
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公开(公告)号:US20120046267A1
公开(公告)日:2012-02-23
申请号:US13025281
申请日:2011-02-11
申请人: Keith R. Hornberger , Dan M. Berger , Xin Chen , Andrew P. Crew , Hanqing Dong , Andrew Kleinberg , An-Hu Li , Lifu Ma , Mark J. Mulvihill , Bijoy Panicker , Kam W. Siu , Arno G. Steinig , James G. Tarrant , Jing Wang , Qinghua Weng , Rajaram Sangem , Ramesh C. Gupta
发明人: Keith R. Hornberger , Dan M. Berger , Xin Chen , Andrew P. Crew , Hanqing Dong , Andrew Kleinberg , An-Hu Li , Lifu Ma , Mark J. Mulvihill , Bijoy Panicker , Kam W. Siu , Arno G. Steinig , James G. Tarrant , Jing Wang , Qinghua Weng , Rajaram Sangem , Ramesh C. Gupta
IPC分类号: A61K31/4355 , A61K31/4545 , A61K31/4725 , A61K31/4709 , A61K31/5377 , C07D495/04 , A61K31/4365 , A61K31/519 , A61K31/5025 , C07D513/04 , A61K31/437 , C07D487/04 , A61K31/4985 , A61K31/502 , C12N9/99 , A61P35/00 , A61P29/00 , C07D491/048
CPC分类号: C07D491/048
摘要: Compounds of Formula 1, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.
摘要翻译: 式1的化合物,如下文所定义:其药学上可接受的盐,合成,中间体,制剂及其治疗方法,包括治疗癌症,例如至少部分由TAK1驱动的肿瘤,或适合于 TAK1抑制剂有效。 本发明并不限于本发明。
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公开(公告)号:US08378104B2
公开(公告)日:2013-02-19
申请号:US13025281
申请日:2011-02-11
申请人: Keith R. Hornberger , Dan M. Berger , Xin Chen , Andrew P. Crew , Hanqing Dong , Andrew Kleinberg , An-Hu Li , Lifu Ma , Mark J. Mulvihill , Bijoy Panicker , Kam W. Siu , Arno G. Steinig , James G. Tarrant , Jing Wang , Qinghua Weng , Rajaram Sangem , Ramesh C. Gupta
发明人: Keith R. Hornberger , Dan M. Berger , Xin Chen , Andrew P. Crew , Hanqing Dong , Andrew Kleinberg , An-Hu Li , Lifu Ma , Mark J. Mulvihill , Bijoy Panicker , Kam W. Siu , Arno G. Steinig , James G. Tarrant , Jing Wang , Qinghua Weng , Rajaram Sangem , Ramesh C. Gupta
IPC分类号: C07D471/02
CPC分类号: C07D491/048
摘要: Compounds of Formula 1, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.
摘要翻译: 式1的化合物,如下文所定义:其药学上可接受的盐,合成,中间体,制剂及其治疗方法,包括治疗癌症,例如至少部分由TAK1驱动的肿瘤,或适合于 TAK1抑制剂有效。 本发明并不限于本发明。
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