- 专利标题: Dual-acting antihypertensive agents
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申请号: US12898999申请日: 2010-10-06
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公开(公告)号: US08106082B2公开(公告)日: 2012-01-31
- 发明人: Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
- 申请人: Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
- 申请人地址: US CA South San Francisco
- 专利权人: Theravance, Inc.
- 当前专利权人: Theravance, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理商 Jeffrey A. Hagenah; Shelley Eberle
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; C07D257/04
摘要:
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US20110021585A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS 公开/授权日:2011-01-27
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