发明授权
US08114654B2 Site-specific incorporation of redox active amino acids into proteins
有权
将氧化还原活性氨基酸的位点特异性掺入蛋白质
- 专利标题： Site-specific incorporation of redox active amino acids into proteins
- 专利标题（中）： 将氧化还原活性氨基酸的位点特异性掺入蛋白质
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申请号： US12806751申请日： 2010-08-20
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公开(公告)号： US08114654B2公开(公告)日： 2012-02-14
- 发明人: Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
- 申请人： Lital Alfonta , Peter G. Schultz , Zhiwen Zhang
- 申请人地址： US CA LaJolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA LaJolla
- 代理机构： Quine Intellectual Property Law Group, P.C.
- 代理商 Edward DesJardins; Gary Baker
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N9/00 ; C12N1/20
摘要：
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
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